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The manuscript was further reviewed and edited by MD.R
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The 28-day bacteriostatic window typically ends before coring becomes a serious issue, but high-frequency dosing protocols (daily or twice-daily) can hit the penetration limit before the chemical stability window closes

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Gu Y, Swisher SG , Ajani JA, Correa AM, Hofstetter W, Liao Z, Komaki RR, Rashid A, Hamilton SR, Wu TT
