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Description
senna (sennosides
Concerns: High in fructose, especially in the form of high-fructose corn syrup (HFCS)

Discovery of 6-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
Fitzpatrick Type I users typically reach 23 shades darker than baseline after 1421 days, while Type IIIIV users may achieve 45 shades deeper
It is implicated in neurotransmission, cell-membrane signaling, lipid transport, and methyl-group metabolism (Goh et al., 2021

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Merris M., Wadsworth W.G., Khamrai U., Bittman R., Chitwood D.J., Lenard J