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TBI traumatic brain injury, GSH glutathione, PTGS2 prostaglandin-endoperoxide synthase 2, 15-LOX 15-lipoxygenase Activation of the Nrf2 pathway In recent years, targeted Nrf2 therapy for TBI has emerged as a prominent research hotspot due to its potential in alleviating oxidative stress and inhibiting ferroptosis [41,60,61]

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In gastric cancer, the effect of two introns of the GPX3 gene, namely rs3805435 and rs3828599, on gene expression and disease susceptibility has been demonstrated (26)

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