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Protein Pept Lett 25:514521 Wu D, Zhao Y, Ren H, Si X, Zhang L, Wang C (2016) Construction of cationic anticancer peptide Temporin-1 CEa liposomes and evaluation of anti-breast cancer activity in vitro

Cons of a Systemic Approach: Lower Local Concentration: The peptide is distributed throughout the body, so the concentration reaching the plantar fascia will be lower than with a direct, local injection

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The choice between them boils down to what the medications guidelines require and patient safety considerations: Use sterile (preservative-free) water when indicated for sensitive situations (newborns, intrathecal use, single-dose needs), and use bacteriostatic water when a multi-dose solution is needed and its safe to do so

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