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Regarding alveolar macrophages, MV with a high tidal volume has been shown to promote autophagy and HMGB1 secretion in cells obtained from mouse lung, thereby increasing the pulmonary inflammatory response [423,424]

[DOI] [PubMed] [Google Scholar] 346.Fang X, et al

However, the precise molecular mechanisms underlying these effects are unknown [51]

Consider these injection site rotation strategies: alternate between left and right sides of the abdomen, include outer thighs and upper arms in rotation, keep injection sites at least one inch apart, and track injection locations to ensure proper rotation

(v) as a cofactor for some enzymes

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