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Somatostatin-SSTR3-GSK3 modulates human T-cell responses by inhibiting OXPHOS

How a metabolite like l-2HG would specifically dampen suppressive genes is not understood

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These samples were introduced in 4% paraformaldehyde (PFA, Santa Cruz Biotechnology, Texas, USA) for 24 h at 4 C for fixation and then were placed in 70% ethanol denatured ACS (denatured with 5% isopropanol and 5% methanol, VWR Chemicals BDH , USA) until subsequent histological study