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These should always be discussed with your doctor

Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration

He says injecting drugs became "normalized" when GLP-1 drugs approved to treat diabetes, such as Ozempic, were also shown to be effective for weight loss and eventually became an approved treatment for obesity

Three ABC transporters are most implicated in this phenotype, ABCB1 or P-gp (P-glycoprotein), ABCG2 or BCRP (Breast Cancer Resistant Protein) and ABCC1 or MRP1 (Multidrug Resistance Protein 1)

Scand J Gastroenterol 44(9):11211131