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For Tirzepatide users, MK-677 presents a trade-off

4 Autophagy x apoptosis The literature extensively debates the protective mechanisms involved in autophagy and whether, in neurodegenerative diseases, this mechanism acts as an inhibitor of cell death or, conversely, enhances death signaling and thus promotes cell death

PMID: 37277863 Carbohydr Polym Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy

More studies using genetic models such as APP null mice or -secretase beta-site APP-cleaving enzyme 1 (BACE1) null mice display a range of dysfunctions such as lowered synaptic plasticity, restricted neurogenesis and cognitive deficits (Cai et al., 2023)

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