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Since then, Siess definition has been adapted to be more comprehensive an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control, and/or molecular damage [7,19,22]. It is essential to appreciate this definition, given the complex cellular redox dynamics that occur in vivo

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doi: 10.1017/S0007114516001811

Junctional adhesion molecules in cerebral endothelial tight junction and brain metastases

Additionally, modification on Cys170 is believed to influence activity as well (Orton and Liebler, 2007), which is also explained by its importance in dimerization (Chang et al., 2001)