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Area covered This review explores the role of pharmacokinetics in the development and optimization of DDS, with an emphasis on basic compartmental models and physiologically-based pharmacokinetic (PBPK) models that are essential for describing drug ADME in the body

Wistar rats were given either LC or saline at a dose of 1 g/kg

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This study revealed that mitochondrial and neuronal damage, along with iron overload and ferroptosis, occur in the hippocampus of STZ-induced type 1 diabetic rats, indicating that SLC40A1-mediated ferroptosis is linked to cognitive impairment in DM [155]