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Zhou, Z., et al

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Phosphorylation and inactivation of TSC1/2 by Cyclin D1CDK4/6 lead to overexpression of mTORC1 in certain types of cancer [54, 55]

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

However, a major drawback of this approach is the low recovery rate with less than 20% of enzymes being successfully characterized, due to the prerequisites of purifying proteins, concentrations, and availabilities of metabolites 17

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