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Once stimulated with oxidative stress, Nrf2 translocate into the nucleus to binds with the anti-oxidant response elements (AREs) and regulate the expression of antioxidant genes, primarily HO-1 and NQO1 [77,78]

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Curcumin has also shown inhibitory effects on the mitochondrial dysfunction in PC12 cells, reducing ROS production and neurotoxicity (R

For this cosmeceutical application, the companies utilized their proprietary transdermal delivery platform (TPM) to directly deliver AOD-9604 through the skin

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