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However, when the limit for storage of TAGs is reached or adipocyte lipolysis is dysregulated, FAs can accumulate in ectopic tissues such as skeletal muscle and the liver leading to insulin insensitivity and T2D (11)

People taking certain common medications including metformin for blood sugar management and proton pump inhibitors for acid reflux also face increased deficiency risk

The Bottom Line: B12 and Weight Management Currently, scientific evidence supporting B12 shots for weight loss in the absence of deficiency is insufficient

[DOI] [PubMed] [Google Scholar] 118.Matson CA, Reid DF, Ritter RC

[5] Thiamine (B) has no known major drug-drug interactions in terms of altering other medications efficacy

It may be beneficial to adopt a potassium-rich pernicious anemia diet