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The exogenous testosterone may alleviate glycolipotoxicity-related mitochondrial dysfunction through the regulation of key enzymes involved in glucose and lipid metabolism, including adipose triglyceride lipase (ATGL), phosphoenolpyruvate carboxykinase (PEPCK), and proteins including glucose transport protein 4 (GLUT4) (129)

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In these studies, the subjects were given 1500 to 3000 mg of acetyl-L-carnitine daily over a period of 3 - 12 months

Furthermore, in prostate cancer cells, miR-185 and miR-342 control lipogenesis and cholesterogenesis by reducing the expression of SREBP-1/2 and downregulating their targeted genes, including fatty acid synthase 96