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Future prospective studies are needed to evaluate precise molecular pathophysiological mechanisms of GGT involvement in atherogenesis and cardiovascular events as well as to assess the impact of GGT-lowering therapies on these clinical outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Sivak S, Nosal V, Bittsansky M, Dluha J, Dobrota D, Kurca E

Gyllensten, U

[DOI] [PubMed] [Google Scholar] 127.Sung WS, Kang HR, Jung CY, Park SS, Lee SH, Kim EJ

Significant gaps remain, particularly the lack of treatments with adequate safety and true disease-modifying potential capable of addressing key pathological drivers such as neuroinflammation, mitochondrial dysfunction, impaired proteostasis and toxic protein aggregation ( Polygonum cuspidatum ), curcumin ( Curcuma longa ), epigallocatechin gallate (EGCG