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In addition, not all reported connections between mTORC2 and autophagy involve cytoplasmic and nuclear functions of FoxO, as Akt directly phosphorylates and inhibits ULK1 ( In addition to the functions of Akt, inhibition of another member of the AGC kinase family, SGK1, by either genetic and pharmacological means, induces autophagy in vitro and in vivo (Liu et al., 2018

[DOI] [PubMed] [Google Scholar] 38.Lagier-Tourenne C., Tazir M., Lpez L.C., Quinzii C.M., Assoum M., Drouot N., Busso C., Makri S., Ali-Pacha L., Benhassine T., et al

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A common approach involves 5-6 days per week dosing with 1-2 rest days