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Hepatocyte Growth Factor (HGF) (294HGN100) was from R&D Systems, Minneapolis, MN

If the mouse failed to escape within 3 min, it was placed inside the escape box

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These proteins have a wide range of functions, including signal transduction, cell proliferation, transcription, apoptosis, neuronal differentiation, cell migration, regulation of ion channels and cell survival ( Alpha-internexin (INA) is a critical component of the cytoskeletal protein network and an essential component of neurofilaments, which are the most abundant protein in the human brain

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Moss et al., 2016)