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[DOI] [PubMed] [Google Scholar] 22.Miller DM, DeSilva D, Pickart L, Aust SD

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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability

The goal here is to explain these markers honestly: what they measure, what they may contribute to a child's overall picture, and what they cannot tell you on their own