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However, they are especially noted as co-factors in catecholamine synthesis (dopamine, norepinephrine, and epinephrine)

Janssen HC, Samson MM, Verhaar HJ

Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice

Studies connect weight gain, memory loss, low energy, and a host of diseases
The Fe atom within active aconitase coordinates with oxygen atoms of citrate and water and acts as a Lewis acid to activate the hydroxyl group of citrate to facilitate the isomerization reaction
