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Operation brain trauma therapy: approach to modeling, therapy evaluation, drug selection, and biomarker assessments for a multicenter pre-clinical drug screening consortium for acute therapies in severe traumatic brain injury

Sodium hydroxide and 99.6% denatured absolute ethanol were supplied by Systerm Chemicals (Selangor, Malaysia)

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Our results thus align with a dual role for Mg in vasculatureacute Mg causes relaxation, but chronic Mg accumulation may lead to compensatory changes that diminish vasodilatory responses

These changes accumulate with time affecting both intracellular and extracellular function and by engaging the receptor for advanced glycation end products (RAGE)

JL: Funding acquisition, Supervision, Writing review & editing, Resources