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Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

Int J Clin Pharmacol Res 1988;8(5):367-376

doi: 10.1177/1534735419846401

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1.2 Distinctive contribution of the present review Several previously published reviews have summarized the biological activities of natural compounds and dietary supplements in breast cancer