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Existing studies have demonstrated that the NF-B signaling is involved in a diverse array of physiological and pathological processes, including immune and inflammatory responses, cell survival and proliferation, metabolism, as well as synaptic plasticity and memory-related activities 81,182,183 (Fig

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Silencing autophagy essential genes ( ATG5/ATG7 ) diminishes cell death in ARPE-19 cells treated with H 2 O 2 [169], suggesting that autophagic cell death is involved in RPE cell death when cells are exposed to excessive oxidative stress