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Description
PMID: 163 RigaultCLe BorgneFTazirBBenaniADemarquoyJ

Traumatic Brain Injury Research Traumatic brain injury (TBI) produces primary mechanical damage (axonal shearing, contusion) and secondary injury cascades including excitotoxicity (glutamate-driven NMDA overactivation), neuroinflammation (microglial activation, pro-inflammatory cytokine production), oxidative stress, and disruption of the blood-brain barrier (BBB)

Liang X, Tian T, Zheng Z, Geng H, Shan Y, Deng X

Bioactivation Although the mercapturate pathway evolved for the detoxification of potentially harmful metabolites and xenobiotics, on occasion, the pathway may result in a toxification (or bioactivation) event

Treatment can repigment patches and slow further spread

Taking into consideration that mutants affected in glutathione biosynthesis exhibited a susceptible phenotype while, under our conditions, none of the tested sulfate transporter mutants did so, the latter did not seem to affect glutathione homeostasis sufficiently to result in increased susceptibility to AITC
