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Flexibility in charge is essential during LNP preparation, maintaining a neutral surface charge at physiological pH to prevent immune responses while becoming positively charged in endosomal environments for membrane fusion and effective cytoplasmic release [40]

En muchos casos, sin embargo, no se puede descartar que estas sustancias iniciales - y, por lo tanto, tambin la arginina hidrocloruro - contengan residuos farmacuticos o metales pesados

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Effect of L-carnitine on carrageenan-induced inflammation in aged rats

Additionally, the mutant huntingtin protein can impair the function of the transcription factor PGC-1, which is crucial for the regulation of antioxidant defenses and mitochondrial biogenesis