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In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines

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External factors such as pollution, sunlight, smoking, unhealthy diets or conditions of nutrient deprivation and intense physical activity, also trigger the production of FR [14,20,21,29]

miRNA truncation We further tested sufficiency of an unoccupied PAZ pocket for mediating ZSWIM8 binding using another approach

The importance of glutamine in preserving the intestinal epithelial barrier function is further supported by several in vitro studies using the cell culture models of intestinal epithelium