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There is no established safe or effective human dose

References Aderem, A

2008 Nov 5;300(17):2012-21

Elevated blood urea nitrogen (BUN) levels can be linked to kidney disease, urinary tract obstruction, dehydration, heart failure, shock, fever, and gastrointestinal bleeding 49,50

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It is crucial that more thorough analyses of behavior accompany the highly technical assays that link a peptide to a regulatory process largely on the basis of anatomical localization and whether food intake is suppressed or stimulated after exogenous, non-physiological, administration
