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However, the authors of these meta-analyses listed some limitations that open the way for carrying out more RCTs to answer questions: a small number of available trials and high heterogeneity between included studies 107

Lamina dura could not be detected in any of the groups

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10 reported a significant reduction in the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) in aqueous humor and a significant increase in aqueous protein carbonyl content, compared to control subjects