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Double knock-out of esyt-2 and tmem-24 had no effect, whereas pdzd-8 and tex-2 double knockouts (DKOs) exhibited aberrant accumulation of NMY-2::GFP puncta (Fig

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2.9.1 Phase 1 A total of 48 female Mus musculus C57BL/6 (FMO3 +/+) strain WT mice, who were 8 weeks old, were divided into eight groups: six groups were based on the compound to be tested and the other two groups were, respectively, the positive control (FMC treatment) and the negative control (only phosphate-buffered saline treatment)