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When IL-8 binds to C-X-C motif receptor 2 (CXCR2) on neutrophils, it mediates the formation of NETs through the CXCR2/PI3K/AKT/ROS axis

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In all MDS subtypes, risk assessment is performed, classifying MDS into lower or higher risk of leukemic progression

References Rousseau M, et al

In response to LPS insult, severe inflammatory reactions are induced, liberating pro-inflammatory cytokines from testicular cells, including Sertoli and Leydig cells, leading to testicular dysfunction (Reddy et al., 2006

In conclusion, despite these limitations, this study is expected to provide reliable evidence for the efficacy of NAC in patients with TRD displaying increased inflammatory activity