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Digestion and metabolism But all that work and filtering out toxins means that liver cells are exposed to a lot of things that can damage them

Ferroptosis was originally coined as a term for the unique form of cell death initated by the small molecules erastin and RAS-selective lethal 3 (RSL3) [3] and is now defined as a form of cell death that involves accumulation of lipid peroxides and that is suppressed by iron chelators and lipophilic antioxidants [2]
Excitotoxicity and oxidative stress during inhibition of energy metabolism

The main gst genes described as polymorphic are those coding for GSTM1-1, GSTT1-1 and GSTP1-1

doi: 10.1016/j.nmni.2021.100897 135 KasprzakM

however, it can undergo a series of one electron reductions and produce reactive intermediates
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