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AKD may progress to CKD or occur during the course of CKD

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As of 2026, neither compound has FDA approval, limiting prescribing to research contexts or off-label use by physicians specializing in obesity medicine or endocrinology

Paneth cells contribute to stem cell homeostasis and anti-microbial defence exclusively in the small intestine, while goblet cells are spread throughout the entire epithelial lining of the digestive tract, and specifically in the colon, these secretory cells produce a thick and well-structured mucus layer responsible for the sequestration of bacteria from the host 34

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