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The key distinction is again the targeted versus systemic approach

Access to individual patient data allowed us to (1) observe minor differences between the original published results and our reanalysis, potentially due to differences in imputation methods for missing data or because original studies have excluded some patients, and hence have used a smaller sample size, (2) overcome potential reporting bias and (3) assess for potential effect modifiers that were not reported in the original publications (eg, comorbidities, additional medications) and explore for treatment-by-covariate interactions on the patient-level

Science-Based Medicine

Endothelial nitric oxide pathway function in the peripheral vasculature of patients with heart failure

The buffer was stored at 4 C and was stable for at least 3 weeks

What the research on hCG dosing frequency reveals is that how you protect it may matter just as much as whether you do