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133 Further, in vitro studies using human cell lines have shown that acetaminophen can cause an immediate, reversible, dose-dependent loss of oxygen uptake followed by a slow, irreversible, dose-independent death and have suggested mechanisms by which acetaminophen may cause toxicity in tissues other than the liver

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The GSR-1b isoform is located in the cytoplasm, whereas the GSR-1a isoform possesses an additional 14 amino acid N -terminal extension which is predicted to include a mitochondrial targeting sequence (MTS) [82]

[80] Li et al

Chronic illness depletes Vitamin C, worsening fatigue, blood pooling, and histamine intolerance