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If our data based on an intense and short exposure to HNE can be extended to an in vivo situation where low concentrations of HNE are produced on a long time scale, the present results suggest that although the amount of DNA adducts is low upon treatment by exogenous HNE, their formation could be favored upon oxidative stress

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In fact, a 2019 study found that both oral glutathione (500 mg/day) and topical 2.0% oxidized glutathione helped brighten skin tone in sun-exposed areas by reducing the melanin index

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