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Emerging evidence indicates that multiple characteristics of patients T cells and CAR-T cells can significantly impact the effectiveness of CAR-T cell therapy

Ultimately, we advocate a rationale to improve the outcome of anti-MET therapies on the basis of thorough consideration of the entire spectrum of MET-mediated biological responses, which implicates adequate patient stratification, meaningful biomarkers and appropriate clinical end points

Alox15-mediated neuron ferroptosis was involved in diabetic peripheral neuropathic pain

This is the fatty, insulating layer that wraps around nerve fibers (axons), much like the plastic coating on an electrical wire

10.1016/S1369-5266(02)00282-0 Curr

In the open field test conducted on the following day, KI mice also displayed a pronounced anxiety-like phenotype, as reflected by reduced center time and fewer center entries, without differences in total distance traveled between genotypes, indicating that these effects were not attributable to altered locomotor activity (Additional file 1: Fig