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While GPX4 was long thought to be the only enzyme that converts potentially lethal lipid hydroperoxides into nonlethal forms, genetic and chemical screens recently identified a complementary protective pathway

Enzymes associated with glucose utilization

Biochim Biophys Acta (2013) 1830:316572.10.1016/j.bbagen.2013.02.009 11 RosenblatMAviramM

Furthermore, an acidic pH induces poor stability of peptideMHC-I complexes, leading to reduction of antigen-presenting capacity of DCs 76,77

Limitations of the present study is the small number of studied cases, especially in neoral ceroid and neurometabolic disorder because of the limited number of cases with confirmed diagnosis before 48 months (the age of studied case) of these two disorders

10.1016/j.abb.2007.02.033 92 FreiB.KimM