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Supplementation of spermidine at 40 mg/day has minimal effects on circulating polyamines: an exploratory double-blind randomized controlled trial in older men

Bannister SC, Smith CA, Roeszler KN, Doran TJ, Sinclair AH, Tizard MLV

Acta Psychiatrica Scandinavica, 81 (5), 432-436

doi: 10.1016/j.ccell.2024.05.011

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The importance of ECM cleavage in this process is evident from the phenotype of mice lacking metalloproteinases: a lack of MMP11 leads to a decreased periductal collagen content and decreased mammary gland morphogenesis 63