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It has been documented that melatonin reduces the increase in Ca 2+ concentration induced by the N-methyl-D-aspartate receptor by inhibiting the activity of mPTP in primary striatal neurons in mice [177]
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Regulation and Manipulation of Glutathione Synthesis The production of glutathione is regulated at multiple levels, with the most important limitations being -ECS activity and cysteine concentration

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Cytokines and inflammatory biomarkers and their association with post-operative delirium: a meta-analysis and systematic review
[DOI] [PubMed] [Google Scholar] [13].Tsutsui H, Kinugawa S, Matsushima S