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Chronic cerebral hypoperfusion (CCH) significantly decreases the expression of proteins such as P62, CTSD, and LAMP1, while increasing the expression of beclin-1, Parkin, and BNIP3, as well as the LC3-II/LC3-I ratio, and the release of cytochrome c from mitochondria to the cytoplasm

National Institute for Health and Care Excellence: Guidelines

Glutathione is a tripeptide composed of three amino acids: cysteine, glycine, and glutamic acid[2]

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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB ( 3.7.4 Radiation-induced injuries and microbial mediation Radiation-induced injuries initiate local and systemic responses, which are closely related to the gut microbiome's integrity

Concurrently, extracellular signal-regulated kinase (ERK), a key member of the MAPK family, plays a critical role in cellular signaling transduction