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CRISPR Cas9 gene editing Target genes were disrupted in MODE-K IECs using the CRISPR/Cas9 system 26

Research indicates that WA promotes apoptosis via several signaling routes

Funding JY is funded by the National Natural Science Foundation of China for young scholars (82103445), Jiangsu province Natural Science Foundation of China for young scholars (SBK2021042832), JH by the National Natural Science Foundation of China for young scholars (82203541) and Xuzhou Science and Technology foundation for young scholars (KC21059)

254 NAD + metabolism programs immunity and inflammation NAD + , along with citrate and succinate, is a novel class of metabolites with inflammatory signaling capacity, linking the NAD + metabolism to the programming of immune responses

Moreover, Kinoshita-Daitoku et al