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Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence

220 HIF-1 expression is strongly associated with increased tumor grade and poor prognosis, as it drives the adaptation of GBM cells to hypoxic stress

Evidence has shown a reduction in mitophagic degradation in the brains of AD patients, particularly in those with elevated levels of total and phosphorylated Tau (pTau) protein, suggesting that Tau may contribute to the observed impairment in this process

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We first reported this when cultured hepatocytes were plated under low density (Lu and Ge 1992a

This is considered a favorable alternative to orally bioavailable PDE5 inhibitors that show poor results in subjects with acute metabolic disease [10, 15, 16]