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NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

19 References Seiwerth, S., Sikiric, P., Grabarevi, ., Zorii, I., Hanevaki, M., Ljubanovi, D., ori, V., Konjevoda, P., Petek, M., Ruman, R., Turkovi, B., Perovi, D., Mikus, D., Jandrijevi, S., Medvidovi, M., Tadi, T., Romac, B., Kos, J., Peri, J., & Kolega, Z

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These findings sparked decades of subsequent research exploring the peptides potential across various wound types

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