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2,61 Cushing remission also reduces the leptin/total adipose tissue and leptin/subcutaneous adipose tissue ratios, but not leptin/visceral adipose tissue ratio, suggesting that the hypercortisolemia in active Cushing syndrome enhances leptin production preferentially in subcutaneous over visceral adipose tissue, 2 consistent with data on healthy individuals showing higher leptin expression in subcutaneous than in visceral adipose tissue

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