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Acute models (DSS/TNBS) show eosinophils can either mediate mucosal damage via granule proteins and pro-inflammatory cytokines or, paradoxically, limit excessive inflammation by regulatory mediators
Mencucci R, Favuzza E, Decandia G, Cennamo M, Giansanti F
Brown J, Jones EY, Forbes BE
In fact, on average, a period of 2.3 years from the first complaint is necessary to get to a definitive diagnosis, excluding those diseases having symptoms, but not causes, common to FM by the evaluation of selected markers
& Ye, B
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