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These were based on the counteracted glaucoma-mydriasis [11], counteracted atropine-mydriasis [12], counteracted effect of NOS-blockade, counteracted L-NAME-miosis, counteraction of NO-system over-stimulation, and counteracted L-arginine-miosis [12]

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Regulatory Considerations TB500 is not approved for human use by regulatory agencies in many countries, presenting legal and quality control challenges