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For this interaction to occur, the structural requirement in the enzyme is the presence of a nucleophilic amino acid side-chain close to the glutathione-docking motif and in a crucial position to interact with the electrophilic motif of glutathione acrylate, as shown in Scheme 9

Participants showed improved clearance of environmental toxins and reduced toxic burden after 8 weeks of supplementation, indicating enhanced detoxification capacity