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[20] Many peptide-based compounds are supplied in lyophilised (freeze-dried) powder form because the peptide structure is more stable when dry and has a longer shelf life

For mTYR, the narrow dual copper-binding site makes it more difficult for arbutin, which has two rings, to fit, especially in the MD-stable conformation of Arbutin_b, where the number of hydrogen bonds between arbutin and the pocket is much lower than in other conformations (Table 2)

Further, these precursors can be converted into other metabolites

1 Introduction Cardio-Cerebrovascular Diseases (CCVDs) are the collective terms for cardiovascular and cerebrovascular diseases, which refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, hyperglycemia and hypertension (Vasan et al., 2001

Patients with stable health and realistic expectations often see the best outcomes

doi: 10.1016/j.ceb.2014.09.010