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Alexandrou A, Armeni E, Kouskouni E, Tsoka E, Diamantis T, Lambrinoudaki I

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which reviewed women treated for Hodgkin's disease between 1961 and 1990 (mean followup, 10 years) concluded that the greatest risk was seen in young women treated before the age of 15 years (RR: 136, 95% CI: 34371), with a significant decline in relative risk with advancing age (above 30 years of age, RR: 0.7, 95% CI: 0.21.8) 92

The researchers surmised that the typical reduction of glutathione in the elderly was due to a lower supply of glycine and cysteine, the precursors to glutathione synthesis, and that upon supplementation, they had the ability to stimulate synthesis and restore levels