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Various cellular signals, such as K+ efflux, Ca2+ signaling, and mitochondrial dysfunction, can activate the NLRP3 inflammasome, necessitating further investigation into their specific roles (168)

In mouse ovaries, melatonin administration protects against ROS production and mitochondrial damage [206]

Significance of the pleiotropic beneficial effects for Roberts concept (stomach cytoprotection/adaptative cytoprotection organoprotection) and Selyes stress coping response concept Of note, Roberts concept (stomach cytoprotection/adaptative cytoprotection organoprotection) on which more focus is put on may be more workable

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These functional changes are based on a fundamental immunometabolic reprogramming, resulting in enhanced mitochondrial oxidative metabolism, thus conferring an increased immunometabolic capacity to human T cells