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In the adult population, a single ingestion of 10-15g (150-250mg/kg) can cause hepatotoxicity, and doses of 20-25g or more are potentially fatal

Dietary Intakes and Nutritional Status of Children with Sickle Cell Disease at the Princess Marie Louise Hospital, AccraA Survey

EUMDS Steering Committee

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They are caused by genetic mutations in hematopoietic stem cells
